Single-cell transcriptomics analysis of zebrafish brain reveals adverse effects of manganese on neurogenesis

X Wang, X Yang, W He, S Zhang, X Song, J Zhang… - Environmental …, 2024 - Elsevier
Manganese (Mn) is considered as an important environmental risk factor for Parkinson's
disease. Excessive exposure to Mn can damage various neural cells and affect the …

Ferroptosis at the crossroads of manganese-induced neurotoxicity: A retrospective study

Y Liu, S Lv, G He, C Wang, C Ou - Toxicology, 2024 - Elsevier
Manganese is an essential trace element, but overexposure can cause neurotoxicity and
subsequent neurodegenerative diseases. Ferroptosis is a form of cell death characterized …

Expression of cytoskeletal proteins (GFAP, Vimentin), proapoptotic protein (Caspase-3) and protective protein (S100) in the epileptic focus in adults and children with …

D Sitovskaya, Y Zabrodskaya, P Parshakov… - International Journal of …, 2023 - mdpi.com
The European Commission of the International League Against Epilepsy (ILAE) has
identified glial mechanisms of seizures and epileptogenesis as top research priorities. The …

Sex‐dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure

OM Ijomone, JD Iroegbu, P Morcillo… - Environmental …, 2022 - Wiley Online Library
Manganese (Mn), although important for multiple cellular processes, has posed
environmental health concerns due to its neurotoxic effects. In recent years, there have been …

Modulatory role of curcumin on cobalt-induced memory deficit, hippocampal oxidative damage, astrocytosis, and Nrf2 expression

RS Oria, GE Anyanwu, EA Esom, JN Nto… - Neurotoxicity …, 2023 - Springer
Chemical overexposure is a growing environmental risk factor for many medical issues.
Cobalt toxicity from environmental, industrial, and medical exposure has previously been …

[HTML][HTML] Co-administration of Spondias mombin and Metformin mitigates Streptozotocin-induced hepatorenal injury

BP Akwu, AJ Ajibade, AZ Abijo, TP Ajibade… - Phytomedicine Plus, 2022 - Elsevier
Background As a result of its many therapeutic properties, including its potent anti-
hyperglycemic effect, the Spondias mombin plant is quickly gaining popularity as a local …

D-Ribose-LCysteine attenuates manganese-induced cognitive and motor deficit, oxidative damage, and reactive microglia activation

GT Akingbade, OM Ijomone, A Imam, M Aschner… - Environmental …, 2022 - Elsevier
Due to overexposure, manganese (Mn) accumulation in the brain can trigger the inhibition of
glutathione synthesis and lead to increased generation of reactive oxygen species (ROS) …

[HTML][HTML] Cobalt exposure triggers impairments in cognitive and anxiety-like behaviors, brain oxidative stress and inflammation, and hippocampo-amygdala …

RS Oria, RB Ben, UG Esomonu, PI Essien… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): Cobalt toxicity has become a health concern in recent years, due to
overexposure resulting in neurological impairments. With a growing interest in the …

Ribose-cysteine and levodopa abrogate Parkinsonism via the regulation of neurochemical and redox activities in alpha-synuclein transgenic Drosophila …

OK Idowu, AA Oremosu, OO Dosumu, AA Mohammed - Fly, 2024 - Taylor & Francis
ABSTRACT Parkinson's disease (PD), the most prevalent type of parkinsonism, is a
progressive neurodegenerative condition marked by several non-motor and motor …

Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK …

RS Oria, GE Anyanwu, JN Nto, JO Ikpa - Journal of Chemical …, 2024 - Elsevier
Curcumin, a bioactive polyphenol derived from turmeric, has been reported to have anti-
inflammatory properties. The current study investigated the anti-inflammatory effect of …