Chronic allograft injury: mechanisms and potential treatment targets
Improving long-term graft survival remains one of the critical challenges facing kidney
transplantation since a great portion of kidney grafts are lost by 10 years after …
transplantation since a great portion of kidney grafts are lost by 10 years after …
The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity
A Goldman, J Roy, B Bodenmiller, S Wanka… - Molecular cell, 2014 - cell.com
To define a functional network for calcineurin, the conserved Ca 2+/calmodulin-regulated
phosphatase, we systematically identified its substrates in S. cerevisiae using …
phosphatase, we systematically identified its substrates in S. cerevisiae using …
Calcineurin targets involved in stress survival and fungal virulence
Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …
Profile of the Pleximmune blood test for transplant rejection risk prediction
R Sindhi, C Ashokkumar, BW Higgs… - Expert review of …, 2016 - Taylor & Francis
SUMMARY The PleximmuneTM test (Plexision Inc., Pittsburgh, PA, USA) is the first cell-
based test approved by the US FDA, which predicts acute cellular rejection in children with …
based test approved by the US FDA, which predicts acute cellular rejection in children with …
Synthesis and evaluation of novel 1H-pyrrolo [2, 3-b] pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3
Y Nakajima, T Inoue, K Nakai, K Mukoyoshi… - Bioorganic & Medicinal …, 2015 - Elsevier
Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets
for the treatment of inflammatory and immune diseases. As a novel class of …
for the treatment of inflammatory and immune diseases. As a novel class of …
[HTML][HTML] Stable and destabilized GFP reporters to monitor calcineurin activity in Saccharomyces cerevisiae
J Diessl, A Nandy, C Schug, L Habernig, S Büttner - Microbial Cell, 2020 - ncbi.nlm.nih.gov
The protein phosphatase calcineurin is activated in response to rising intracellular Ca 2+
levels and impacts fundamental cellular processes in organisms ranging from yeast to …
levels and impacts fundamental cellular processes in organisms ranging from yeast to …
[HTML][HTML] Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms
TJ Borges, N Murakami, IT Lape, RB Gassen, K Liu… - JCI insight, 2021 - ncbi.nlm.nih.gov
The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent
inhibitory pathway involved in immune regulation and is a potential therapeutic target in …
inhibitory pathway involved in immune regulation and is a potential therapeutic target in …
Synthesis and evaluation of 1H-pyrrolo [2, 3-b] pyridine derivatives as novel immunomodulators targeting Janus kinase 3
Y Nakajima, T Tojo, M Morita, K Hatanaka… - Chemical and …, 2015 - jstage.jst.go.jp
Janus kinases (JAKs) have been known to play crucial roles in modulating a number of
inflammatory and immune mediators. Here, we describe a series of 1H-pyrrolo [2, 3-b] …
inflammatory and immune mediators. Here, we describe a series of 1H-pyrrolo [2, 3-b] …
Design, synthesis, and evaluation of 4, 6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3
Y Nakajima, N Aoyama, F Takahashi, H Sasaki… - Bioorganic & Medicinal …, 2016 - Elsevier
In organ transplantation, T cell-mediated immune responses play a key role in the rejection
of allografts. Janus kinase 3 (JAK3) is specifically expressed in hematopoietic cells and …
of allografts. Janus kinase 3 (JAK3) is specifically expressed in hematopoietic cells and …
The neurology of solid organ transplantation
JD Avila, S Živković - Current Neurology and Neuroscience Reports, 2015 - Springer
Transplantation is the rescue treatment for end-stage organ failure with more than 110,000
solid organs transplantations performed worldwide annually. Recent advances in …
solid organs transplantations performed worldwide annually. Recent advances in …