A survey of methods and tools to detect recent and strong positive selection

P Pavlidis, N Alachiotis - Journal of Biological Research-Thessaloniki, 2017 - Springer
Positive selection occurs when an allele is favored by natural selection. The frequency of the
favored allele increases in the population and due to genetic hitchhiking the neighboring …

How to increase our belief in discovered statistical interactions via large-scale association studies?

K Van Steen, JH Moore - Human genetics, 2019 - Springer
The understanding that differences in biological epistasis may impact disease risk,
diagnosis, or disease management stands in wide contrast to the unavailability of widely …

A survey of trusted computing solutions using FPGAS

PD Rosero-Montalvo, Z István, W Hernandez - IEEE Access, 2023 - ieeexplore.ieee.org
Ensuring the security and privacy of computation and data management in the cloud and
edge is an ever-important requirement. There are several working solutions today for trusted …

High-performance epistasis detection in quantitative trait GWAS

NT Weeks, GR Luecke, BM Groth… - … Journal of High …, 2018 - journals.sagepub.com
epiSNP is a program for identifying pairwise single nucleotide polymorphism (SNP)
interactions (epistasis) in quantitative-trait genome-wide association studies (GWAS). A …

High-speed exhaustive 3-locus interaction epistasis analysis on FPGAs

JC Kässens, L Wienbrandt… - Journal of …, 2015 - Elsevier
Epistasis, the interaction between genes, has become a major topic in molecular and
quantitative genetics. It is believed that these interactions play a significant role in genetic …

Parallel pairwise epistasis detection on heterogeneous computing architectures

J González-Domínguez, S Ramos… - … on Parallel and …, 2015 - ieeexplore.ieee.org
Development of new methods to detect pairwise epistasis, such as SNP-SNP interactions, in
Genome-Wide Association Studies is an important task in bioinformatics as they can help to …

[图书][B] Biopolymers for medical applications

JM Ruso, PV Messina - 2017 - books.google.com
This book presents an experimental and computational account of the applications of
biopolymers in the field of medicine. Biopolymers are macromolecules produced by living …

Computing acceleration to genome-wide association study based on CPU/FPGA heterogeneous system

X Liu, R Wang, C Shi, C Zou, W Zhu - ACM SIGAPP Applied Computing …, 2024 - dl.acm.org
Genome Wide Association Study (GWAS) reveals the influence of single nucleotide
polymorphisms (SNP) and other genetic markers on the complex genetic disease traits …

WISH-R–a fast and efficient tool for construction of epistatic networks for complex traits and diseases

VAO Carmelo, LJA Kogelman, MB Madsen… - BMC …, 2018 - Springer
Background Genetic epistasis is an often-overlooked area in the study of the genomics of
complex traits. Genome-wide association studies are a useful tool for revealing potential …

Fiuncho: a program for any-order epistasis detection in CPU clusters

C Ponte-Fernández, J González-Domínguez… - The Journal of …, 2022 - Springer
Epistasis can be defined as the statistical interaction of genes during the expression of a
phenotype. It is believed that it plays a fundamental role in gene expression, as individual …