Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …

Marine-derived cyclic imine toxins, portimine A and portimine B, have attracted attention
because of their chemical structure and notable anti-cancer therapeutic potential …

Photoaffinity probes are routinely utilized to identify proteins that interact with small
molecules. However, despite this common usage, resolving the specific sites of these …

The use of photo-affinity reagents for the mapping of noncovalent small molecule–protein
interactions has become widespread. Recently, several 'fully-functionalized'(FF) chemical …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

Fungi and antifungal compounds are relevant to the United Nation's Sustainable
Development Goals. However, the modes‐of‐action of antifungals—whether they are …

Lysophosphatidylserine (lyso-PS) has emerged as yet another important signaling
lysophospholipid in mammals, and deregulation in its metabolism has been directly linked to …

Folates are indispensable for plant development, but their molecular mode of action remains
elusive. We synthesized a probe,“5-F-THF-Dayne,” comprising 5-formyl-tetrahydrofolate …

Glutathione peroxidase 4 (GPX4) emerges as a promising target for the treatment of therapy-
resistant cancer through ferroptosis. Thus, there is a broad interest in the development of …