The physiological heterogeneity of platelets leads to diverse responses and the formation of
discrete subpopulations upon platelet stimulation. Procoagulant platelets are an example of …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Endothelial cells (ECs) normally form an anticoagulant surface under physiological
conditions, but switch to support coagulation following pathogenic stimuli. This switch …

Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles,
including exosomes, microvesicles and apoptotic bodies, which are released into the …

Platelets play a key role in maintaining hemostasis. However, dysregulated platelet
activation can lead to pathological thrombosis or bleeding. Once a platelet gets activated, it …

The transbilayer movement of phosphatidylserine from the inner to the outer leaflet of the
membrane bilayer during platelet activation is associated with the release of procoagulant …

Disordered coagulation contributes to death in sepsis and lacks effective treatments.
Existing markers of disseminated intravascular coagulation (DIC) reflect its sequelae rather …

MFG‐E8 was initially identified as a principle component of the Milk Fat Globule, a
membrane‐encased collection of proteins and triglycerides that bud from the apical surface …

A subpopulation of platelets fulfills a procoagulant role in hemostasis and thrombosis by
enabling the thrombin burst required for fibrin formation and clot stability at the site of …