Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Cancer initiation and progression follow complex molecular and structural changes in the
extracellular matrix and cellular architecture of living tissue. However, it remains poorly …

The mechanical properties of soft tissues can often be strongly correlated with the
progression of various diseases, such as myocardial infarction (MI). However, the dynamic …

Understanding liver tissue mechanics, particularly in the context of liver pathologies like
fibrosis, cirrhosis, and carcinoma, holds pivotal significance for assessing disease severity …

Bioprinting offers tremendous potential in the fabrication of functional tissue constructs for
replacement of damaged or diseased tissues. Among other fabrication methods used in …

Matrix rigidity sensing regulates a large variety of cellular processes and has important
implications for tissue development and disease. However, how cells probe matrix rigidity …

The quality of life of ageing populations is increasingly determined by age-related changes
to the mechanical properties of numerous biological tissues. Degradation and mechanical …