The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Nitric oxide (NO) has emerged as an important signal molecule in plants, having myriad
roles in plant development. In addition, NO also orchestrates both biotic and abiotic stress …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic
and can injure cellular longevity. Here we show that CD8+ memory T (TM) cells mobilize the …

Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the
molecular mechanisms of this protection are poorly understood,. Nitric oxide-based cellular …

Normal brain functioning relies on high aerobic energy production provided by
mitochondria. Failure to supply a sufficient amount of energy, seen in different brain …

S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently
dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S …

Brain metastasis (BM) is a leading cause of mortality in patients with non-small cell lung
cancer (NSCLC). However, the molecular mechanisms underlying BM of NSCLC remain …

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are
characterized by progressive degeneration of synapses and neurons. Accumulation of …

Nitric oxide (NO) is a signaling molecule that plays important roles in diverse biological
processes and thus its dysregulation is involved in the pathogenesis of various disorders. In …