Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Glutamate excitotoxicity plays an important role in the development of secondary injuries
that occur following traumatic brain injury (TBI), and contributes significantly to expansion of …

l‐Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …

Glutamate transporters (GluTs) prevent the accumulation of glutamate and influence the
occupancy of receptors at synapses. The ability of extrasynaptic NMDA receptors and …

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission
significantly contribute to heroin relapse vulnerability. In animal models, heroin self …

Glutamate is the major excitatory neurotransmitter in the mammalian CNS. The
spatiotemporal profile of the glutamate concentration in the synapse is critical for excitatory …