Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor
microemboli, in biological fluids has long been described. Intensive research on single …

Simple Summary Circulating tumor cell clusters (CTC clusters) seem to play a primary role in
the metastatic spread of cancer, the main cause of death associated with this disease. The …

In embryonic development and throughout life, there are some cells can exhibit phenotypic
plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In …

Morphogenesis, the process by which tissues develop into functional shapes, requires
coordinated mechanical forces. Most current literature ascribes contractile forces derived …

Cells utilize calcium channels as one of the main signaling mechanisms to sense changes
in the extracellular space and convert these changes to intracellular signals. Calcium …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …