In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

Retrotransposons are genomic DNA sequences that copy themselves to new genomic
locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated
(ATM) protein, a signaling kinase involved in the DNA damage response. We present …

Repair of single-ended DNA double-strand breaks (seDSBs) by homologous recombination
(HR) requires the generation of a 3′ single-strand DNA overhang by exonuclease activities …

The recognition, signalling and repair of DNA double strand breaks (DSB) involves the
participation of a multitude of proteins and post-translational events that ensure …

When DNA breaks, the ends need to be stabilized and processed to facilitate subsequent
repair, which can occur by either direct but error-prone end-joining with another broken DNA …