Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …

From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic
reticulum (ER), newly synthesized integral membrane proteins are subject to a complex …

Notch signaling induced by cell surface ligands is critical to development and maintenance
of many eukaryotic organisms. Notch and its ligands are integral membrane proteins that …

Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …

The heptahelical G protein‐coupled receptor (GPCR) family includes∼ 900 members and is
the largest family of signaling receptors encoded in the mammalian genome. G protein …

Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in
renal collecting duct cells. Using mass spectrometry, we previously demonstrated four …

The function of many receptors and transport proteins that reside at the surface of the cell is
regulated by endocytosis and postendocytic trafficking. Modification of receptors and …

Epithelial Na+ absorption is regulated by Nedd4-2, an E3 ubiquitin-protein ligase that
reduces expression of the epithelial Na+ channel ENaC at the cell surface. Defects in this …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …