Biochemical and structural basis of sialic acid utilization by gut microbes

A Bell, E Severi, CD Owen, D Latousakis… - Journal of Biological …, 2023 - ASBMB
The human gastrointestinal (GI) tract harbors diverse microbial communities collectively
known as the gut microbiota that exert a profound impact on human health and disease. The …

SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-Acetyl sialylation in virus–host interaction

CH Kim - International journal of molecular sciences, 2020 - mdpi.com
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus
disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into …

Modified sialic acids on mucus and erythrocytes inhibit influenza A virus hemagglutinin and neuraminidase functions

KN Barnard, BK Alford-Lawrence, DW Buchholz… - Journal of …, 2020 - Am Soc Microbiol
Sialic acids (Sia) are the primary receptors for influenza viruses and are widely displayed on
cell surfaces and in secreted mucus. Sia may be present in variant forms that include O …

Reversible O-Acetyl Migration within the Sialic Acid Side Chain and Its Influence on Protein Recognition

Y Ji, A Sasmal, W Li, L Oh, S Srivastava… - ACS chemical …, 2021 - ACS Publications
O-Acetylation is a common naturally occurring modification of carbohydrates and is
especially widespread in sialic acids, a family of nine-carbon acidic monosaccharides. O …

Sialosides Containing 7-N-Acetyl Sialic Acid Are Selective Substrates for Neuraminidases from Influenza A Viruses

AS Kooner, Y Yuan, H Yu, H Kang… - ACS infectious …, 2022 - ACS Publications
Sialidases or neuraminidases are sialic-acid-cleaving enzymes that are expressed by a
broad spectrum of organisms, including pathogens. In nature, sialic acids are …