Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …
antibodies. Recently, aptamers have garnered increased interest due to their unique …
Aptamer based biosensor platforms for neurotransmitters analysis
Neurotransmitters control the signal transmission in chemical synapses via their release
from the presynaptic neuron and subsequent binding and activation of receptors in the …
from the presynaptic neuron and subsequent binding and activation of receptors in the …
SCORe: SARS-CoV-2 omicron variant RBD-binding DNA aptamer for multiplexed rapid detection and pseudovirus neutralization
During the COVID-19 (coronavirus disease 2019) pandemic, several SARS-CoV-2 variants
of concern emerged, including the Omicron variant, which has enhanced infectivity and …
of concern emerged, including the Omicron variant, which has enhanced infectivity and …
Aptamers targeting membrane proteins for sensor and diagnostic applications
Many biological processes (physiological or pathological) are relevant to membrane
proteins (MPs), which account for almost 30% of the total of human proteins. As such, MPs …
proteins (MPs), which account for almost 30% of the total of human proteins. As such, MPs …
Aptamer‐based strategies against SARS‐CoV‐2 viruses
Y Huang, X Chen, J Zhang, W Tian, S Liu… - …, 2023 - Wiley Online Library
The COVID‐19 pandemic, caused by SARS‐CoV‐2, has seriously threatened human life
and security in recent years and has had a serious impact on economic development. A …
and security in recent years and has had a serious impact on economic development. A …
Development of a Novel DNA Aptamer Targeting Colorectal Cancer Cell‐Derived Small Extracellular Vesicles as a Potential Diagnostic and Therapeutic Agent
BS Cha, YJ Jang, ES Lee, DY Kim… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) as the second leading cause of global cancer deaths poses critical
challenges in clinical settings. Cancer‐derived small extracellular vesicles (sEVs), which are …
challenges in clinical settings. Cancer‐derived small extracellular vesicles (sEVs), which are …
Kinetic capillary electrophoresis in screening oligonucleotide libraries for protein binders
ATH Le, SM Krylova, SN Krylov - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Identifying protein binders is the first step in drug discovery. The combinatorial approach, in
which a library of compounds is subjected to affinity screening against a target protein, is a …
which a library of compounds is subjected to affinity screening against a target protein, is a …
Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics
Y Dong, J Wang, L Chen, H Chen, S Dang… - Chemical Society …, 2024 - pubs.rsc.org
Nucleic acid aptamers are oligonucleotide chains with molecular recognition properties.
Compared with antibodies, aptamers show advantages given that they are readily produced …
Compared with antibodies, aptamers show advantages given that they are readily produced …
The Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for the Detection of SARS-CoV-2 S Proteins on the Surface of Cold-Chain Food …
X Li, J Wang, G Yang, X Fang, L Zhao, Z Luo, Y Dong - Molecules, 2024 - mdpi.com
The COVID-19 pandemic over recent years has shown a great need for the rapid, low-cost,
and on-site detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In …
and on-site detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In …
Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS‐CoV‐2 Variants
Many DNA aptamers have been reported to target the spike protein (S‐protein) of SARS‐
CoV‐2. These aptamers display different affinities or recognize different epitopes of the S …
CoV‐2. These aptamers display different affinities or recognize different epitopes of the S …