Nemaline myopathy (NM) is among the most common non-dystrophic congenital
myopathies (incidence 1: 50.000). Hallmark features of NM are skeletal muscle weakness …

Recent advances in nemaline myopathy : Current Opinion in Neurology Recent advances in
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Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident:
it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To …

Muscle dysfunction and wasting are predictors of mortality in advanced COPD and
malignancies. Redox imbalance and enhanced protein catabolism are underlying …

The association between reduced myofilament force-generating capacity (Fmax) and heart
failure (HF) is clear, however the underlying molecular mechanisms are poorly understood …

Rationale: Diaphragm weakness in critically ill patients prolongs ventilator dependency and
duration of hospital stay and increases mortality and healthcare costs. The mechanisms …

The congenital myopathies are a diverse group of genetic skeletal muscle diseases, which
typically present at birth or in early infancy. There are multiple modes of inheritance and …

Background Cachexia is a life‐threatening condition observed in several pathologies, such
as cancer or chronic diseases. Interleukin 10 (Il10) gene transfer is known to improve …

The myosin-directed chaperone UNC-45B is essential for sarcomeric organization and
muscle function from Caenorhabditis elegans to humans. The pathological impact of UNC …

Objective Thin filament myopathies are among the most common nondystrophic congenital
muscular disorders, and are caused by mutations in genes encoding proteins that are …