RNA editing enzymes: structure, biological functions and applications
D Zhang, L Zhu, Y Gao, Y Wang, P Li - Cell & Bioscience, 2024 - Springer
With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …
different RNA modifications have been identified. However, only a few of these modifications …
Adenosine-to-Inosine RNA editing in cancer: molecular mechanisms and downstream targets
Abstract Adenosine-to-inosine (A-to-I), one of the most prevalent RNA modifications, has
recently garnered significant attention. The A-to-I modification actively contributes to …
recently garnered significant attention. The A-to-I modification actively contributes to …
METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control
P Zhao, L Xia, D Chen, W Xu, H Guo, Y Xu… - … Hematology & Oncology, 2024 - Springer
Background RNA modifications have been proven to play fundamental roles in regulating
cellular biology process. Recently, maladjusted N7-methylguanosine (m7G) modification …
cellular biology process. Recently, maladjusted N7-methylguanosine (m7G) modification …
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
Z Shi, J Li, J Ding, Y Zhang, W Min, Y Zhu, Y Hou… - Leukemia, 2024 - nature.com
Recent extensive studies on the genomic and molecular profiles of acute myeloid leukemia
(AML) have expanded the treatment options, including, a range of compounds represented …
(AML) have expanded the treatment options, including, a range of compounds represented …
Non‐m6A RNA modifications in haematological malignancies
Dysregulated RNA modifications, stemming from the aberrant expression and/or malfunction
of RNA modification regulators operating through various pathways, play pivotal roles in …
of RNA modification regulators operating through various pathways, play pivotal roles in …
Cancer Plasticity in Therapy Resistance: Mechanisms and Novel Strategies
X Niu, W Liu, Y Zhang, J Liu, J Zhang, B Li, Y Qiu… - Drug Resistance …, 2024 - Elsevier
Therapy resistance poses a significant obstacle to effective cancer treatment. Recent
insights into cell plasticity as a new paradigm for understanding resistance to treatment: as …
insights into cell plasticity as a new paradigm for understanding resistance to treatment: as …
Genetic variants of m6A modification genes are associated with survival of HBV‐related hepatocellular carcinoma
S Liu, J Li, M Qiu, Y Liu, Q Wen, Q Lin… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) is a dynamic and reversible modification process
involving in a series of important biological and pathophysiological processes, including the …
involving in a series of important biological and pathophysiological processes, including the …
[HTML][HTML] Role of RNA modifications in Blood development and Regeneration
Blood development and regeneration require rapid turnover of cells, and RNA modifications
play a key role in it via regulating stemness and cell fate regulation. RNA modifications effect …
play a key role in it via regulating stemness and cell fate regulation. RNA modifications effect …
Getting to the core of ADAR2 activity in AML
K Steel, C Jamieson - Blood, 2023 - ashpublications.org
In an insightful article in this issue of Blood, Guo et al 1 identify the RNA editing enzyme
ADAR2 (adenosine deaminase acting on RNA2) as a core tumor suppressor in core binding …
ADAR2 (adenosine deaminase acting on RNA2) as a core tumor suppressor in core binding …