Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

M Delfi, R Sartorius, M Ashrafizadeh, E Sharifi, Y Zhang… - Nano Today, 2021 - Elsevier
Self-assembled peptides and proteins possess tremendous potential as targeted drug
delivery systems and key applications of these well-defined nanostructures reside in anti …

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

R Sartorius, M Trovato, R Manco, L D'Apice… - npj Vaccines, 2021 - nature.com
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …

Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

Immunogenicity of innovative and biosimilar monoclonal antibodies

E Doevendans, H Schellekens - Antibodies, 2019 - mdpi.com
The development of hybridoma technology for producing monoclonal antibodies (mAbs) by
Kohler and Milstein (1975) counts as one of the major medical breakthroughs, opening up …

Viruses as tools in gene therapy, vaccine development, and cancer treatment

M bin Umair, FN Akusa, H Kashif, F Butt, M Azhar… - Archives of …, 2022 - Springer
Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate
horizontal gene transfer has made them useful tools for gene therapy, vaccine development …

[HTML][HTML] Type of RNA packed in VLPs impacts IgG class switching—implications for an influenza vaccine design

AC Gomes, ES Roesti, A El-Turabi, MF Bachmann - Vaccines, 2019 - ncbi.nlm.nih.gov
Nucleic acid packed within virus-like particles (VLPs) is shown to shape the immune
response and to induce stronger B cell responses in different immunisation models. Here …

[HTML][HTML] Components of a HIV-1 vaccine mediate virus-like particle (VLP)-formation and display of envelope proteins exposing broadly neutralizing epitopes

JF Rosengarten, S Schatz, T Wolf, S Barbe, J Stitz - Virology, 2022 - Elsevier
The sequence diversity of HIV-1 is the biggest hurdle for the design of a prophylactic
vaccine. Mosaic (Mos) antigens consisting of synthetically shuffled epitopes from various …

At‐line multi‐angle light scattering detector for faster process development in enveloped virus‐like particle purification

P Pereira Aguilar… - Journal of separation …, 2019 - Wiley Online Library
At‐line static light scattering and fluorescence monitoring allows direct in‐process tracking of
fluorescent virus‐like particles. We have demonstrated this by coupling at‐line multi‐angle …

A thermostable oral SARS-CoV-2 vaccine induces mucosal and protective immunity

B Bellier, A Saura, LA Luján, CR Molina… - Frontiers in …, 2022 - frontiersin.org
An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing
disease, but also in preventing virus transmission. It should also be well accepted by the …

Cancer targeted biomimetic drug delivery system

R Wang, H Yan, A Yu, L Ye, G Zhai - Journal of Drug Delivery Science and …, 2021 - Elsevier
Till now, cancer is one of the most serious diseases causing a high death ratio and a huge
challenge to human health. Nanocarriers with the advantages of improved bioavailability …