The melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor
(MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily …

The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

The human melanocortin-1 receptor (MC1R) is a G-protein coupled receptor involved in the
regulation of pigmentation. Several MC1R variant alleles are associated with red hair, fair …

We report the development of new bioactive coatings of biomaterials based on the alternate
deposition of oppositely charged polyelectrolytes. We selected polylysine (PLL) and poly …

The characterization of the melanocortin 1 receptor (MC1R) expressed on human
melanocytes and the findings that certain mutations in the POMC gene or the MC1R gene …

Over the years there has been much debate as to whether α‐MSH has a role as a
pigmentary hormone in humans. There are two main reasons for this. First, despite the …

The original strain of proopiomelanocortin (POMC)-deficient mice (Pomc−/−) was generated
by homologous recombination in 129X1/SvJ (A w/A w)-derived embryonic stem cells using a …

The seven transmembrane domain melanocortin-1 receptor (Mc1r) encoded by the coat
color extension gene (E) plays a key role in the signaling pathway of melanin synthesis …

The effects of apple polyphenols on melanogenesis in B16 mouse melanoma cells were
investigated. The inhibitory effect of apple polyphenols was stronger than that of arbutin or …

Ultraviolet B (UVB) radiation in the skin induces pigmentation that protects cells from further
UVB damage and reduces photocarcinogenesis. Although the mechanisms are not well …