Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-
communicable disease deaths. Glycolysis is a conserved and rigorous biological process …

Glycolysis is an important step in respiration and provides energy for cellular processes.
Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, plays an important role …

Simple Summary Winter cold stress is a major environmental factor affecting cattle industry
production in northern China. Determining the effects of prolonged cold stress on the …

The purpose of this study was to investigate the anti-fatigue effect of natural Lycium
barbarum polysaccharide (LBP) during exercise, develop a functional anti-fatigue …

Dapagliflozin (DAPA) confers significant protection against heart and kidney diseases.
However, whether DAPA can alleviate type 4 cardiorenal syndrome (CRS-4)-related …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon
and rectum, which features recurrent mucosal inflammation. The excessive production of …

Background Forkhead box M1 (FOXM1) is a member of the Forkhead box (Fox) transcription
factor family. It regulates cell mitosis, cell proliferation, and genome stability. However, the …

We aimed to investigate the role of renal pericyte pyruvate kinase M2 (PKM2) in the
progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The role of PKM2 …

Genetic abnormalities in histone methyltransferases (HMTs) frequently occur in diffuse large
B-cell lymphoma (DLBCL) and are related to its progression. SET and MYND domain …

Voltage-gated potassium channels play a crucial role in cellular repolarization and are
potential therapeutic targets in neuroinflammatory disorders and neurodegenerative …