The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Pattern recognition receptors (PRRs) are part of the innate immune response and were
originally discovered for their role in recognizing pathogens by ligating specific pathogen …

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

The inflammasome is an intracellular multiprotein complex involved in the activation of
caspase-1 and the processing of the proinflammatory cytokines interleukin-1 β (IL-1 β) and …

Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive
decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It …

Pyroptosis pathway is closely related to inflammation. However, Celastrol effect on
pyroptosis pathway after spinal cord injury (SCI) are poorly understood. We studied the anti …

Prion diseases are neurodegenerative disorders characterized by the accumulation of
misfolded prion protein, spongiform changes in the brain, and brain inflammation as a result …

Spinal cord injury (SCI) is a severe injury characterized by neuroinflammation and oxidative
stress. Taxifolin is exhibits anti-inflammatory and antioxidative activities in neurologic …