Everyday activities require adaptive decision-making and control over our actions to achieve
our goals. Sub-regions within the cortex are widely reported to regulate these choices. Here …

The medial prefrontal cortex (mPFC) has long been considered a critical site in action
control. However, recent evidence indicates that the contribution of cortical areas to goal …

Tobacco use is the leading cause of preventable death worldwide, and relapse during
abstinence remains the critical barrier to successful treatment of tobacco addiction. During …

Evidence now indicates that the chronic consumption of high-calorie foods, such as a high-
fat diet (HFD), is associated with impaired control over food-seeking, yet the extent of this …

In everyday life, we mentally represent possible consequences of our behaviors and
integrate specific outcome values into existing knowledge to inform decisions. The medial …

The ability to learn the reward-value and action-outcome contingencies in dynamic
environment is critical for flexible adaptive behavior and development of effective …

Reinforcer devaluation is a task often used to model flexible goal-directed behavior. Here,
we inactivated basolateral amygdala (BLA), orbitofrontal cortex (OFC), mediodorsal …

Conditioned taste aversion (CTA) is an essential behavior for animal survival. Conditioned
animals show avoidance and decreased palatability to a conditioned stimulus (CS) on CTA …

Our daily lives are full of habits. Yet, even though we know them intimately, habits are
surprisingly hard to pin down in laboratory settings in order to study them and their basis in …

Habits help to reduce cognitive load and free up resources required for dynamic goal-
directed decisions. The prefrontal cortex has been largely implicated in the latter, but cortical …