Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y Xia, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Navigating the Intersection: Diabetes and Alzheimer's Intertwined Relationship

MB Kale, HM Bhondge, NL Wankhede… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) and Diabetes mellitus (DM) exhibit comparable
pathophysiological pathways. Genetic abnormalities in APP, PS-1, and PS-2 are linked to …

Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease

SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and
motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes …

Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health

NL Wankhede, SR Kopalli, MD Dhokne, DJ Badnag… - Mitochondrion, 2024 - Elsevier
Mitochondria are singular cell organelles essential for many cellular functions, which
includes responding to stress, regulating calcium levels, maintaining protein homeostasis …

Molecular understanding of ER-MT communication dysfunction during neurodegeneration

SS Sammeta, TA Banarase, SR Rahangdale… - Mitochondrion, 2023 - Elsevier
Biological researchers are seeing organelles in a new light. These cellular entities have
been believed to be singular and distinctive structures that performed specialized purposes …

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

W Xie, S Koppula, MB Kale, LS Ali… - Frontiers in …, 2024 - frontiersin.org
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly
recognized for its intricate relationship with mitochondria, the cellular powerhouses …

Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders

L Li, T Liang, T Jiang, Y Li, L Yang, L Wu… - Critical Reviews in …, 2024 - Taylor & Francis
The aim of this review was to evaluate the feasibility of treating sleep disorders using novel
gut microbiota intervention strategies. Multiple factors can cause sleep disorders, including …

The effect of month and breed on plasma adrenocorticotropic hormone concentrations in equids

AE Durham, JF Potier, L Huber - The Veterinary Journal, 2022 - Elsevier
Use of plasma adrenocorticotropic hormone (ACTH) concentrations for the diagnosis of
PPID in equids requires awareness of other factors that might influence ACTH …

Mitophagy regulation in aging and neurodegenerative disease

TA Banarase, SS Sammeta, NL Wankhede… - Biophysical …, 2023 - Springer
Mitochondria are the primary cellular energy generators, supplying the majority of
adenosine triphosphate through oxidative phosphorylation, which is necessary for neuron …

Valorization of different low-grade date (Phoenix dactylifera L.) fruit varieties: A study on the bioactive properties of polyphenolic extracts and their stability upon in vitro …

M Hamdi, H Mostafa, M Aldhaheri, P Mudgil… - Plant Physiology and …, 2023 - Elsevier
Nowadays, the development of suitable strategies for the management and valorization of
agri-food products is one of the most important challenges worldwide. In this context, the …