Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

α-Lactalbumin, amazing calcium-binding protein

EA Permyakov - Biomolecules, 2020 - mdpi.com
α-Lactalbumin (α-LA) is a small (Mr 14,200), acidic (pI 4–5), Ca2+-binding protein. α-LA is a
regulatory component of lactose synthase enzyme system functioning in the lactating …

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

J Yang, T Wang, L Zhao, VK Rajasekhar… - Nature biomedical …, 2020 - nature.com
Theranostic agents should ideally be renally cleared and biodegradable. Here, we report
the synthesis, characterization and theranostic applications of fluorescent ultrasmall gold …

Unveiling the MUFA–cancer connection: insights from endogenous and exogenous perspectives

Z Guo, KF Bergeron, M Lingrand… - International journal of …, 2023 - mdpi.com
Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the
field of cancer due to their potential role in its prevention and treatment. MUFAs can be …

Direct observation of alpha-lactalbumin, adsorption and incorporation into lipid membrane and formation of lipid/protein hybrid structures

E Rao, V Foderà, M Leone, V Vetri - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
The interaction between proteins and membranes is of great interest in biomedical and
biotechnological research for its implication in many functional and dysfunctional processes …

Structures and mechanisms of formation of liprotides

JN Pedersen, HKS Frislev, JS Pedersen… - Biochimica et Biophysica …, 2020 - Elsevier
Many proteins form complexes called liprotides with oleic acid and other cis-fatty acids
under conditions where the protein is partially unfolded. The complexes vary in structure …

Role of charge and hydrophobicity in liprotide formation: A molecular dynamics study with experimental constraints

J Nedergaard Pedersen, PWJM Frederix… - …, 2018 - Wiley Online Library
Bovine α‐lactalbumin (aLA) and oleate (OA) form a complex that has been intensively
studied for its tumoricidal activity. Small‐angle X‐ray scattering (SAXS) has revealed that …

Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments

JS Hansen, TH Tran, M Cavalera, S Paul… - Molecular biology …, 2020 - academic.oup.com
A challenging question in evolutionary theory is the origin of cell division and plausible
molecular mechanisms involved. Here, we made the surprising observation that complexes …

Augmenting the cytotoxicity of oleic acid-protein complexes: Potential of target-specific antibodies

M Hoque, J Gupta, M Saleemuddin - Biochimie, 2017 - Elsevier
Abstract HAMLET (Human Alpha-Lactalbumin Made LEthal to Tumor cells), a complex of
oleic acid (OA) with partially unfolded human α-lactalbumin, shows remarkable toxicity …

[HTML][HTML] Cancer–to DIY or not to DIY

P Clayton - Cancer, 2021 - foodpharmacy.se
Cancer treatment used to be barbarous. The first weapons in the war against cancer, the
nitrogen mustards, were originally developed as weapons of war. Today, cancer treatment is …