α-Lactalbumin (α-LA) is a small (Mr 14,200), acidic (pI 4–5), Ca2+-binding protein. α-LA is a regulatory component of lactose synthase enzyme system functioning in the lactating …
Theranostic agents should ideally be renally cleared and biodegradable. Here, we report the synthesis, characterization and theranostic applications of fluorescent ultrasmall gold …
Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the field of cancer due to their potential role in its prevention and treatment. MUFAs can be …
E Rao, V Foderà, M Leone, V Vetri - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
The interaction between proteins and membranes is of great interest in biomedical and biotechnological research for its implication in many functional and dysfunctional processes …
Many proteins form complexes called liprotides with oleic acid and other cis-fatty acids under conditions where the protein is partially unfolded. The complexes vary in structure …
Bovine α‐lactalbumin (aLA) and oleate (OA) form a complex that has been intensively studied for its tumoricidal activity. Small‐angle X‐ray scattering (SAXS) has revealed that …
JS Hansen, TH Tran, M Cavalera, S Paul… - Molecular biology …, 2020 - academic.oup.com
A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes …
M Hoque, J Gupta, M Saleemuddin - Biochimie, 2017 - Elsevier
Abstract HAMLET (Human Alpha-Lactalbumin Made LEthal to Tumor cells), a complex of oleic acid (OA) with partially unfolded human α-lactalbumin, shows remarkable toxicity …
Cancer treatment used to be barbarous. The first weapons in the war against cancer, the nitrogen mustards, were originally developed as weapons of war. Today, cancer treatment is …