Targeted anti-biofilm therapy: Dissecting targets in the biofilm life cycle

F Bu, M Liu, Z Xie, X Chen, G Li, X Wang - Pharmaceuticals, 2022 - mdpi.com
Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After
biofilm formation, the bacteria present improve drug tolerance and multifactorial defense …

A peptide-binding domain shared with an Antarctic bacterium facilitates Vibrio cholerae human cell binding and intestinal colonization

CJ Lloyd, S Guo, B Kinrade, H Zahiri… - Proceedings of the …, 2023 - National Acad Sciences
Vibrio cholerae, the causative agent of the disease cholera, is responsible for multiple
pandemics. V. cholerae binds to and colonizes the gastrointestinal tract within the human …

Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and …

M Sherik, R Eves, S Guo, CJ Lloyd, KE Klose… - Mbio, 2024 - Am Soc Microbiol
Many pathogenic Gram-negative bacteria use repeats-in-toxin adhesins for colonization and
biofilm formation. In the cholera agent Vibrio cholerae, flagellar-regulated hemagglutinin A …

Adhesin domains responsible for binding bacteria to surfaces they colonize project outwards from companion split domains

LA Graham, T Hansen, Y Yang, M Sherik… - Proteins: Structure …, 2024 - Wiley Online Library
Bacterial adhesins attach their hosts to surfaces that the bacteria will colonize. This surface
adhesion occurs through specific ligand‐binding domains located towards the distal end of …

Structures of Fibrillar Adhesins That Mediate Bacteria–Host Interactions and Biofilm Formation

PL Davies, S Guo - Biofilm Matrix, 2024 - Springer
This chapter explores the structural and functional mechanisms of fibrillar adhesins involved
in bacteria-host interactions and biofilm formation. Fibrillar adhesins are non-fimbrial …

The role of Bartonella adhesin A and fibronectin in adherence of Bartonella henselae to endothelial cells

DJ Vaca Llerena - 2023 - publikationen.ub.uni-frankfurt.de
The capacity of pathogenic bacteria to adhere to host cells and to avoid subsequent
clearance by the host´ s immune response is the initial and most decisive step leading to …

Structure-Activity Relationships in Adhesins from Environmental Bacteria

M Yang - 2023 - search.proquest.com
The aggregation of bacteria into the form of biofilms is a measure of their success in
colonizing biotic and abiotic surfaces. Biofilm communities provide the sheltering bacteria …

Characterization of the Peptide-Binding Domain of FrhA in Vibrio cholerae

CJ Lloyd - 2023 - search.proquest.com
Vibrio cholerae is a highly motile organism that employs a single polar flagellum as a major
virulence factor determinant for intestinal colonization and environmental proliferation …