Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …

Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate
glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells …

Abstract The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is
responsible for more human mortality than any other single pathogen. Progression to active …

Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains
remain undefined. By characterizing high and low transmission strains of M. tuberculosis in …

Mycobacterium tuberculosis (Mtb) has evolved to evade host innate immunity by interfering
with macrophage functions. Interleukin-1β (IL-1β) is secreted by macrophages after the …

Viral co-infections have been implicated in worsening tuberculosis (TB) and during the
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical
outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …