Our understanding of G protein-coupled receptor (GPCR) activation has evolved during the
last ten years, both at a molecular level thanks to the resolution of several crystal structures …

The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca2+). Since the identification of …

Post-implantation, vicinity acquired oxidative stress and bacterial infections lead to
apoptosis with eventual bone-resorption and implant failure, respectively. Thus, in order to …

Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+] cyt) in pulmonary arterial smooth
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …

Understanding the molecular events that regulate osteoblast differentiation is essential for
the development of effective approaches to bone regeneration. In this study, we analysed …

Aims The local concentration of extracellular Ca2+ ([Ca2+] o) in bone microenvironment is
accumulated during bone remodeling. In the present study we investigated whether …

The aim of this work was to develop a bioactive bone substitute with an effective
antibacterial ability based on a cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) …

A novel bioactive bone substitute with improved osteoblastic performance and effective
antibacterial activity was developed, using a completely new approach based on samarium …

The proinflammatory status of adipose tissue has been linked to the metabolic and
cardiovascular consequences of obesity. Human adipose cells express the calcium sensing …

Pertaining to real-life applications (by scaling up) of hydroxyapatite (HA)-based materials,
herein is a study illustrating the role of carbon nanotube (CNT) reinforcement with ceria …