Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

Metallophenolomics: a novel integrated approach to study complexation of plant phenolics with metal/metalloid ions

VS Fedenko, M Landi, SA Shemet - International Journal of Molecular …, 2022 - mdpi.com
Plant adaptive strategies have been shaped during evolutionary development in the
constant interaction with a plethora of environmental factors, including the presence of …

New organometallic ruthenium (II) compounds synergistically show cytotoxic, antimetastatic and antiangiogenic activities for the treatment of metastatic cancer

Y Wang, J Jin, L Shu, T Li, S Lu… - … A European Journal, 2020 - Wiley Online Library
In this study, we newly designed and synthesized a small library of ten structurally related C,
N‐cyclometalated ruthenium (II) complexes containing various pyridine‐functionalized NHC …

“Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

JH de Araujo-Neto, APM Guedes, CM Leite… - Inorganic …, 2023 - ACS Publications
Upon exploration of the chemistry of the combination of ruthenium/arene with anthraquinone
alizarin (L), three new complexes with the general formulas [Ru (L) Cl (η6-p …

Highly cytotoxic osmium (II) compounds and their ruthenium (II) analogues targeting ovarian carcinoma cell lines and evading cisplatin resistance mechanisms

J Hildebrandt, N Häfner, D Kritsch, H Görls… - International journal of …, 2022 - mdpi.com
(1) Background: Ruthenium and osmium complexes attract increasing interest as next
generation anticancer drugs. Focusing on structure-activity-relationships of this class of …

Lapachol in the design of a new ruthenium (II)-diphosphine complex as a promising anticancer metallodrug

KM Oliveira, J Honorato, FC Demidoff… - Journal of Inorganic …, 2021 - Elsevier
The preparation of two new Ru (II)/diphosphine complexes containing Lapachol (Lap) and
Lawsone (Law):(1)[Ru (Lap)(dppm) 2] PF 6 and (2)[Ru (Law)(dppm) 2] PF 6, where dppm …

Ru (II)/diclofenac-based complexes: DNA, BSA interaction and their anticancer evaluation against lung and breast tumor cells

KM Oliveira, J Honorato, GR Goncalves… - Dalton …, 2020 - pubs.rsc.org
Ruthenium (II) diclofenac-based complexes of the general formula [Ru (dicl)(P–P)(bpy)] PF6
[dicl= diclofenac, bpy= 2, 2′-bipyridine, and P–P= 1, 4′-bis (diphenylphosphino) butane …

A novel ruthenium (II) complex with lapachol induces G2/M phase arrest through aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate …

RA De Grandis, KM Oliveira, APM Guedes… - Frontiers in …, 2021 - frontiersin.org
Lapachol is a well-studied natural product that has been receiving great interest due to its
anticancer properties that target oxidative stress. In the present work, two novel lapachol …

Recent trends in the design and delivery strategies of ruthenium complexes for breast cancer therapy

U Das, U Basu, P Paira - Dalton Transactions, 2024 - pubs.rsc.org
As the most frequent and deadly type of cancer in women, breast cancer has a high
propensity to spread to the brain, bones, lymph nodes, and lungs. The discovery of cisplatin …

A novel ruthenium (ii) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

AE Graminha, J Honorato, RS Correa… - Dalton …, 2021 - pubs.rsc.org
This work describes the synthesis of three new ruthenium (II) complexes with gallic acid and
derivatives of the general formula [Ru (L)(dppb)(bipy)] PF6, where L= gallate (GAC) …