Epithelial-to-mesenchymal transitions (EMTs) are phenotypic plasticity processes that confer
migratory and invasive properties to epithelial cells during development, wound-healing …

Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications
in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has …

Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …

Interactions between the microbiota and mammalian host are essential for defense against
infection, but the microbial-derived cues that mediate this relationship remain unclear. Here …

ChIP-Seq (chromatin immunoprecipitation sequencing) has provided the advantage for
finding motifs as ChIP-Seq experiments narrow down the motif finding to binding site …

Thymic epithelial cell differentiation, growth and function depend on the expression of the
transcription factor Foxn1; however, its target genes have never been physically identified …

Summary H3K27M mutations resulting in epigenetic dysfunction are frequently observed in
diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a …

MEME-ChIP is a web-based tool for analyzing motifs in large DNA or RNA data sets. It can
analyze peak regions identified by ChIP-seq, cross-linking sites identified by CLIP-seq and …

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common
alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and …

Tumor DNA circulates in the plasma of cancer patients admixed with DNA from
noncancerous cells. The genomic landscape of plasma DNA has been characterized in …