Polymer‐based mRNA delivery strategies for advanced therapies
W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …
Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
Toward a global understanding of chemical pollution: a first comprehensive analysis of national and regional chemical inventories
Chemicals, while bringing benefits to society, may be released during their lifecycles and
possibly cause harm to humans and ecosystems. Chemical pollution has been mentioned …
possibly cause harm to humans and ecosystems. Chemical pollution has been mentioned …
In vitro toxicity from a physical perspective of polyethylene microplastics based on statistical curvature change analysis
Microplastics which are gradually and randomly decompose into small fragment by
exposure of physical and biological external stress are emerging as a significant threat to …
exposure of physical and biological external stress are emerging as a significant threat to …
In vitro chemical and physical toxicities of polystyrene microfragments in human-derived cells
With the increase in plastic production, a variety of toxicological studies on microplastics
have been conducted as microplastics can be accumulated in the human body and cause …
have been conducted as microplastics can be accumulated in the human body and cause …
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in
many life-threatening diseases. Owing to the significant advances in siRNA design, many …
many life-threatening diseases. Owing to the significant advances in siRNA design, many …
Poly (beta-amino ester) s as gene delivery vehicles: challenges and opportunities
Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …
biomedical applications, with delivery vehicles including viruses and non-viral materials …
Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy
J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
Polyplex designs for improving the stability and safety of RNA therapeutics
Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …
[HTML][HTML] Polymer-and lipid-based gene delivery technology for CAR T cell therapy
Chimeric antigen receptor T cell (CAR T cell) therapy is a revolutionary approach approved
by the FDA and EMA to treat B cell malignancies and multiple myeloma. The production of …
by the FDA and EMA to treat B cell malignancies and multiple myeloma. The production of …