Companion dogs have served an important role in cancer immunotherapy research. Sharing
similar environments and diets with humans, dogs naturally develop many of the same …

The ability to genetically redirect the antigenic specificity of T cells using chimeric antigen
receptors (CAR) has led to unprecedented durable clinical remissions in human patients …

The canine spontaneous cancer model is increasingly utilized to evaluate new combined
cancer immunotherapy approaches. While the major leukocyte subsets and phenotypes are …

Chimeric antigen receptor (CAR) T–adoptive cell therapy has transformed the treatment of
human hematologic malignancies. However, its application for the treatment of solid tumors …

9 Gene Editing and Gene Therapy in Oncology Page 1 9 Gene Editing and Gene Therapy
in Oncology WESLEY A. WIERSON 1*, ALEX M. ABEL 1, ELIZABETH L. SIEGLER 2 …

Chimeric antigen receptor (CAR) T cell therapy has achieved unprecedented clinical
outcomes in patients with relapsed/refractory B cell leukemias; however, response rates in …

Chimeric antigen receptors (CARs) have demonstrated remarkable promise in human
oncology over the past two decades, yet similar strategies in veterinary medicine are still in …

8 Cancer Immunotherapy Page 1 8 Cancer Immunotherapy NICOLA MASON 1* AND
STEVEN DOW 2* 1University of Pennsylvania, Philadelphia, Pennsylvania, USA; …

Simple Summary The pilot study explored a type of adoptive cell therapy in canine oral
malignant melanoma, by collecting peripheral blood mononuclear cells from tumor-bearing …

With rapid advances in gene editing and gene therapy technologies, the development of
genetic-, cell-, or protein-based cures to disease is no longer the realm of science fiction but …