Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Dynamic monitoring of intracellular ubiquitin (Ub) conjugates is instrumental to
understanding the Ub regulatory machinery. Although many biochemical approaches have …

The central role of the chaperome in maintaining cellular proteostasis has seen numerous
viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 …

The formation of noncovalent complexes by mixing of positively charged polymers with
negatively charged oligonucleotides (ONs) is a widely explored concept in nanomedicine to …

The cellular uptake routes of peptides and proteins are complex and diverse, often
handicapping therapeutic success. Understanding their mechanisms of internalization …

Ubiquitination plays a crucial role in controlling various biological processes such as
translation, DNA repair and immune response. Protein degradation for example, is one of …

Cell-penetrating peptides (CPPs) are commonly modified to increase their cellular uptake,
alter the mechanism of penetration or enhance their endosomal release. Earlier, we …

Extracellular vesicles (EVs) have garnered significant attention in biomedical applications.
However, the rapid, efficient, and unbiased separation of EVs from complex biological fluids …