Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

The history of antiretroviral therapy and of its implementation in resource-limited areas of the world

S Vella, B Schwartländer, SP Sow, SP Eholie… - Aids, 2012 - journals.lww.com
HIV/AIDS not only represents the most severe epidemic in modern times, but also the
greatest public health challenge in history. The response of the scientific community has …

Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patients

YW Chiu, I Teitelbaum, M Misra… - Clinical Journal of the …, 2009 - journals.lww.com
Pill Burden, Adherence, Hyperphosphatemia, and Quality of Li... : Clinical Journal of the
American Society of Nephrology Pill Burden, Adherence, Hyperphosphatemia, and Quality of …

Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional …

WM Han, MG Law, M Egger, K Wools-Kaloustian… - The lancet HIV, 2021 - thelancet.com
Background As countries move towards the UNAIDS's 95-95-95 targets and with strong
evidence that undetectable equals untransmittable, it is increasingly important to assess …

Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review

RE Barth, MFS van der Loeff, R Schuurman… - The Lancet infectious …, 2010 - thelancet.com
Following large-scale roll-out of antiretroviral therapy in sub-Saharan Africa, the non-clinical
efficacy of antiretroviral therapy has received little attention. We aimed to systematically …

Better adherence with once-daily antiretroviral regimens: a meta-analysis

JJ Parienti, DR Bangsberg, R Verdon… - Clinical Infectious …, 2009 - academic.oup.com
Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether
such regimens are associated with better adherence to treatment is controversial. We …

Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions

JC Gaardbo, HJ Hartling, J Gerstoft… - Journal of Immunology …, 2012 - Wiley Online Library
Treatment of HIV‐infected patients with highly active antiretroviral therapy (HAART) usually
results in diminished viral replication, increasing CD4+ cell counts, a reversal of most …

Drug adherence in chronic kidney diseases and dialysis

M Burnier, M Pruijm, G Wuerzner… - Nephrology Dialysis …, 2015 - academic.oup.com
Poor long-term adherence and persistence to drug therapy is universally recognized as one
of the major clinical issues in the management of chronic diseases, and patients with renal …

Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection

L Shen, RF Siliciano - Journal of allergy and clinical immunology, 2008 - Elsevier
Although highly active antiretroviral therapy (HAART) can reduce HIV-1 viremia to levels that
are below the limit of detection of clinical assays, the virus persists in reservoirs, and trace …

[HTML][HTML] Viral suppression after 12 months of antiretroviral therapy in low-and middle-income countries: a systematic review

JH McMahon, JH Elliott, S Bertagnolio… - Bulletin of the World …, 2013 - SciELO Public Health
OBJECTIVE: To establish estimates of viral suppression in low-and middle-income countries
(LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency …