Structural insight into PPARγ ligands binding
A Farce, N Renault, P Chavatte - Current Medicinal Chemistry, 2009 - ingentaconnect.com
Peroxisome Proliferator Activated Receptors (PPARs) are a family of three related nuclear
receptors first cloned in 1990. Their involvement in glucidic and lipidic homeostasis quickly …
receptors first cloned in 1990. Their involvement in glucidic and lipidic homeostasis quickly …
Virtual screening as a technique for PPAR modulator discovery
Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic
and preventive efficacy against disease. Our current focus is on the in silico screening and …
and preventive efficacy against disease. Our current focus is on the in silico screening and …
An alternate mode of binding of the polyphenol quercetin with serum albumins when complexed with Cu (II)
Polyphenols find wide use as antioxidants, cancer chemopreventive agents and metal
chelators. The latter activity has proved interesting in many aspects. We have probed the …
chelators. The latter activity has proved interesting in many aspects. We have probed the …
Pharmacophore modeling and parallel screening for PPAR ligands
P Markt, D Schuster, J Kirchmair, C Laggner… - Journal of computer …, 2007 - Springer
We describe the generation and validation of pharmacophore models for PPARs, as well as
a large scale validation of the parallel screening approach by screening PPAR ligands …
a large scale validation of the parallel screening approach by screening PPAR ligands …
Computational study of the binding orientation and affinity of PPARγ agonists: Inclusion of ligand-induced fit by cross-docking
The peroxisome proliferator-activated receptors (PPARs) comprise a family of three nuclear
receptor isoforms (γ, β/δ, α) which are key regulators of metabolism and inflammation. A …
receptor isoforms (γ, β/δ, α) which are key regulators of metabolism and inflammation. A …
Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling
Abstract Peroxisome Proliferator-Activated Receptor γ (PPARγ) activators have drawn great
recent attention in the clinical management of type 2 diabetes mellitus, prompting several …
recent attention in the clinical management of type 2 diabetes mellitus, prompting several …
Characterization of new PPARγ agonists: Benzimidazole derivatives—importance of positions 5 and 6, and computational studies on the binding mode
In this and previous studies we investigated the importance of partial structures of
Telmisartan on PPARγ activation. The biphenyl-4-ylmethyl moiety at N1 and residues at C2 …
Telmisartan on PPARγ activation. The biphenyl-4-ylmethyl moiety at N1 and residues at C2 …
In silico discovery of resveratrol analogues as potential agents in treatment of metabolic disorders
Background: Resveratrol was demonstrated to act as partial agonist of PPAR-γ receptor,
which opens up the possibility for its use in the treatment of metabolic disorders …
which opens up the possibility for its use in the treatment of metabolic disorders …
Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators
C Liao, B Liu, L Shi, J Zhou, XP Lu - European journal of medicinal …, 2005 - Elsevier
Based on the structural characters of PPAR modulators, a virtual combinatorial library
containing 1226, 625 compounds was constructed using SMILES strings. Selected ADME …
containing 1226, 625 compounds was constructed using SMILES strings. Selected ADME …
Study of the interactions between edaglitazone and ciglitazone with PPARγ and their antiplatelet profile
C Muñoz-Gutiérrez, C Sepúlveda, J Caballero… - Life Sciences, 2017 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription
factor with an important role in lipid metabolism, inflammation and cardiovascular diseases …
factor with an important role in lipid metabolism, inflammation and cardiovascular diseases …