Challenges in clinical development of mesenchymal stromal/stem cells: concise review

I Mastrolia, EM Foppiani, A Murgia… - Stem cells …, 2019 - academic.oup.com
Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a
substantial interest among the scientific community because of their differentiation plasticity …

Neurodegeneration and neuro-regeneration—Alzheimer's disease and stem cell therapy

V Vasic, K Barth, MHH Schmidt - International journal of molecular …, 2019 - mdpi.com
Aging causes many changes in the human body, and is a high risk for various diseases.
Dementia, a common age-related disease, is a clinical disorder triggered by …

Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy

FU Rehman, Y Liu, Q Yang, H Yang, R Liu… - Journal of Controlled …, 2022 - Elsevier
Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete
prevailing remedy. Although the synthetic nanotechnology-based approaches exhibit …

Amyloid Precursor Protein and Alzheimer's Disease

KS Orobets, AL Karamyshev - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late …

[HTML][HTML] Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease

AF Neves, C Camargo, C Premer, JM Hare… - Experimental …, 2021 - Elsevier
Mesenchymal stem cell (MSC) administration is a novel and promising therapeutic approach
for Alzheimer's disease (AD). Focusing on an intervention easily translatable into clinical …

Mesenchymal stromal cells for the treatment of Alzheimer's disease: Strategies and limitations

S Regmi, DD Liu, M Shen, BD Kevadiya… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a major cause of age-related dementia and is characterized by
progressive brain damage that gradually destroys memory and the ability to learn, which …

Therapeutic effects of mesenchymal stromal cells require mitochondrial transfer and quality control

AN Mukkala, M Jerkic, Z Khan, K Szaszi… - International Journal of …, 2023 - mdpi.com
Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs)
have been the focus of intense preclinical research and clinical implementation for decades …

Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia

H Tsivion-Visbord, N Perets, T Sofer, L Bikovski… - Translational …, 2020 - nature.com
Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not
adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for …

The future of stem cell therapies of Alzheimer's disease

ZB Wang, ZT Wang, Y Sun, L Tan, JT Yu - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) places a heavy burden on the global economy. There is no
effective disease-modifying treatment available at present. Since the advent of induced …

Therapeutic potential of stem cells for treatment of neurodegenerative diseases

H Ahmadian-Moghadam, MS Sadat-Shirazi… - Biotechnology …, 2020 - Springer
Neurodegenerative diseases are caused by a loss of neurons within the peripheral or
central nervous system. Inadequate repairability in the central nervous system and failure of …