CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

A major limitation of current humanized mouse models is that they primarily enable the
analysis of human-specific pathogens that infect hematopoietic cells. However, most human …

Background Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus
(CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated …

The presence of preformed donor-specific antibodies in transplant recipients increases the
risk of acute antibody-mediated rejection (AMR). Results of an open-label single-arm trial to …

As the global elderly population grows, it is socioeconomically and medically critical to
provide diverse and effective means of mitigating the impact of aging on human health …

Human cytomegalovirus (HCMV) is a large DNA herpesvirus that is highly prevalent in the
human population. HCMV can result in severe direct and indirect pathologies under …

Human cytomegalovirus (CMV) is a highly prevalent herpesvirus worldwide. According to
the Centers for Disease Control and Prevention (CDC) and the World Health Organization …

Vaccination against human cytomegalovirus (CMV) infection remains high priority. A
recombinant form of a protein essential for CMV entry, glycoprotein B (gB), demonstrated …

Maribavir was approved by the US Food and Drug Administration in November 2021 for the
treatment of adult and pediatric patients with post-transplant cytomegalovirus (CMV) …