Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

Background Activated microglia play an essential role in inflammatory responses elicited in
the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are …

There is an urgent need to identify modifiable environmental risk factors that reduce the
incidence of Alzheimer's disease (AD). The B‐like vitamin choline plays key roles in body …

N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the
class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg …

Increasing evidence strongly supports the key role of neuroinflammation in the
pathophysiology of neurodegenerative diseases, such as Alzheimer's disease …

Abstract Sphingosine 1‐phosphate receptors (S1 PR) are G protein‐coupled and compose
a family with five subtypes, S1P1R–S1P5R. The drug Gilenya®(Novartis, Basel …

Background Acute-phase response is a systemic reaction to environmental/inflammatory
insults and involves production of acute-phase proteins, including serum amyloid A (SAA) …

Background: Uncontrolled neuroinflammation and microglia activation lead to cellular and
tissue damage contributing to neurodegenerative and neurological disorders. Spirulina …

The use of a complete nutritional approach seems increasingly promising to combat chronic
inflammation. The choice of healthy sources of carbohydrates, fats, and proteins, associated …