Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Adiponectin is an insulin-sensitizing adipokine with protective effects against a cluster of
obesity-related metabolic and cardiovascular disorders. The adipokine exerts its insulin …

The mechanism by which hyperuricemia induced-endothelial dysfunction contributes to
cardiovascular diseases (CVDs) is not yet fully understood. In the present study, we used …

The beneficial metabolic effects of adiponectin which confer insulin-sensitizing and anti-
diabetic effects are well established. Skeletal muscle is an important target tissue for …

APPLs (adaptor proteins containing the pleckstrin homology domain, phosphotyrosine
binding domain and leucine zipper motif) are multifunctional adaptor proteins that bind to …

Maternal adiponectin (ADN) levels are inversely correlated with birth weight, and ADN
infusion in pregnant mice down-regulates placental nutrient transporters and decreases fetal …

Defects in adiponectin action have been implicated in the development of cardiac
dysfunction in obesity and diabetes. Cardiac fibroblasts play an important role in regulating …

Leptin has been implicated in tumorigenesis and tumor progression, particularly in obese
patients. As a multifunctional adaptor protein, APPL1 (containing pleckstrin homology …

Previous evidence indicates that adiponectin possesses antifibrogenic activity in inhibiting
liver fibrosis. Therapeutic strategies, however, are limited by adiponectin quaternary …

Adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1)
plays a central role as the main contributing factor in the adiponectin and insulin signaling …