[PDF][PDF] HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
[PDF][PDF] HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals
Monoclonal antibody 10-1074 targets the V3 glycan supersite on the HIV-1 envelope (Env)
protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here …
protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here …
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
L Xu, A Pegu, E Rao, N Doria-Rose, J Beninga… - Science, 2017 - science.org
The development of an effective AIDS vaccine has been challenging because of viral
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …
[PDF][PDF] Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
Native‐like Env trimers as a platform for HIV‐1 vaccine design
RW Sanders, JP Moore - Immunological reviews, 2017 - Wiley Online Library
We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
[PDF][PDF] Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
[PDF][PDF] Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
LE McCoy, MJ van Gils, G Ozorowski, T Messmer… - Cell reports, 2016 - cell.com
A major advance in the search for an HIV vaccine has been the development of a near-
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …