Abstract ABSTRACT: Colony-Stimulating Factor-1 Receptor (CSF1R) is a receptor tyrosine
kinase that controls the differentiation and maintenance of most tissue-resident …

The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully
understand the intratumoral regulation of different cell types and their activities …

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Mitochondrial stress may be a secondary contributor to muscle weakness in inherited
muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention …

Skeletal muscle has a high capacity to repair and remodel in response to damage, largely
through the action of resident muscle stem cells, termed satellite cells. Satellite cells are …

Renal cell carcinoma (RCC) is one of the most common tumors that afflicts the urinary
system, accounting for 90–95% of kidney cancer cases. Although its incidence has …

In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage,
dysregulation of repair, fibro-fatty replacement, and weakness. We develop methodology to …

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or
through self-renewal. While the presence of a nurturing niche is likely crucial to support the …

Loss of muscle mass is a common manifestation of chronic disease. We find the canonical
Wnt pathway to be activated in mesenchymal progenitors (MPs) from cancer-induced …

IFNγ is traditionally known as a proinflammatory cytokine with diverse roles in antimicrobial
and antitumor immunity. Yet, findings regarding its sources and functions during the …