Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Advances in genomics technology over recent years have led to the surprising discovery
that the genome is far more pervasively transcribed than was previously appreciated. Much …

A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …