Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …

Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main
pathological change, is the major source of pain and disability worldwide. Despite current …

The use of stem cells in regenerative medicine, including tissue engineering and
transplantation, has generated a great deal of enthusiasm. Mesenchymal stromal/stem cells …

With nearly 30 years of progress, tissue engineering has shown promise in developing
solutions for tissue repair and regeneration. Scaffolds, together with cells and growth factors …

Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis,
degenerative disc disease, and sarcopenia, present major challenges in the aging …

Purpose The extracellular matrix (ECM) labyrinthine network secreted by mesenchymal
stem cells (MSCs) provides a microenvironment that enhances cell adherence, proliferation …

Intra-articular injection of anti-inflammatory drugs can be a promising strategy for recovery of
injured articular cartilage. We prepared a series of injectable thermo-sensitive composite …

Since articular cartilage possesses only a weak capacity for repair, its regeneration potential
is considered one of the most important challenges for orthopedic surgeons. The treatment …

Osteoarthritis leads to the progressive decay of articular cartilage. Due to its intrinsic
avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss …

Mesenchymal stem cells (MSCs) represent a very attractive cell source for tissue
engineering applications aiming at the generation of artificial bone substitutes. The use of …