Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

Targeting of human epidermal growth factor type 2 (HER2) using monoclonal antibodies,
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …

Tumor-associated macrophages constitute a major component of the stroma of solid tumors,
encompassing distinct subpopulations with different characteristics and functions. We aimed …

Programmed death ligand 1 (PD-L1) is an immune regulatory ligand that binds to the T-cell
immune check point programmed death 1. Tumor expression of PD-L1 is correlated with …

Introduction Radiolabeled nanobodies are exciting new probes for molecular imaging due to
high affinity, high specificity and fast washout from the blood. Here we present the labeling of …

The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

The concept of positron emission tomography (PET) based imaging was developed more
than 40 years ago. It has been a widely adopted technique for detecting and staging …

Platelet-derived growth factor receptor β (PDGFRβ) is a transmembrane tyrosine kinase
receptor involved, for example, in angiogenesis. Overexpression and excessive signaling of …

A promising strategy to enable patient stratification for targeted therapies is to monitor the
target expression in a tumor by radionuclide molecular imaging. Affibody molecules (7 kDa) …

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the
rapid, stable, and chemoselective 18F-labeling of thiol-containing (bio) molecules under …