Viruses and mobile genetic elements are molecular parasites or symbionts that coevolve
with nearly all forms of cellular life. The route of virus replication and protein expression is …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …

Abstract The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …

We examined transposable element (TE) content of 248 placental mammal genome
assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that …

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …

Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

Broad paradigms of vertebrate genomic repeat element evolution have been largely shaped
by analyses of mammalian and avian genomes. Here, based on analyses of genomes …

Transposable elements (TEs) are genomic sequences that can move, multiply, and often
form sizable fractions of vertebrate genomes. Fish belong to a unique group of vertebrates …

Piwi-interacting RNAs (piRNAs) are a very recently discovered class of small non-coding
RNAs (ncRNAs), with approximately 20,000 piRNA genes already identified within the …