Bee venom composition: From chemistry to biological activity

AA Abd El-Wahed, SAM Khalifa, BY Sheikh… - Studies in natural …, 2019 - Elsevier
Nature has provided many drugs capable of treating and alleviating human diseases.
Terrestrial plants, bacteria, insects, fungi, and bee products have played major roles in …

Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

C Duffy, A Sorolla, E Wang, E Golden… - NPJ precision …, 2020 - nature.com
Despite decades of study, the molecular mechanisms and selectivity of the biomolecular
components of honeybee (Apis mellifera) venom as anticancer agents remain largely …

[HTML][HTML] Paracelsus' legacy in the faunal realm: Drugs deriving from animal toxins

T Fischer, R Riedl - Drug discovery today, 2022 - Elsevier
Given the vast number of venomous and poisonous animals, it is surprising that only
relatively few animal-derived toxins have been explored and made their way into marketed …

Formulation, characterization and cellular toxicity assessment of a novel bee-venom microsphere in prostate cancer treatment

SE El-Didamony, RI Amer, GH El-Osaily - Scientific Reports, 2022 - nature.com
Bee venom (BV) is a toxin produced naturally by honey bees with several toxic and
therapeutic efficacies. It is used in the treatment of different cancer kinds like renal, hepatic …

Mellitin peptide quantification in seasonally collected crude bee venom and its anticancer effects on myelogenous K562 human leukaemia cell line

M Obeidat, IF Al-Khraisat, DMM Jaradat… - … Medicine and Therapies, 2023 - Springer
Background Apitherapy is an emerging field in cancer research, particularly in developing
communities. The potency of Melittin (MEL), a major constituent in bee venom is accounted …

[HTML][HTML] Anti-breast cancer activity on MCF-7 cells of melittin from Indonesia's Apis cerana: An in vitro study

K Lischer, SRA Sitorus, BW Guslianto… - Asian Pacific journal …, 2021 - ncbi.nlm.nih.gov
Objective: Breast cancer is the most common case of cancers. Apitheraphy has been
traditionally used for abundance diseases. This study aims to evaluate and compare the anti …

An overview of the bioactive compounds, therapeutic properties and toxic effects of apitoxin

A Pascoal, MM Estevinho, AB Choupina… - Food and chemical …, 2019 - Elsevier
Apitoxin, also known as bee venom (BV), is produced in two specialized abdominal glands
of worker bees and is used as a defence weapon of bees' colony (Choi et al., 2015; Zhang et …

Apis mellifera anatoliaca Venom Exerted Anti-Inflammatory Activity on LPS-Stimulated Mammalian Macrophages by Reducing the Production of the Inflammatory …

S Sevin, İ Kivrak, H Tutun, R Uyar, F Ayaz - Applied Biochemistry and …, 2023 - Springer
Extraction and characterization of natural products provide the opportunity to expand our
arsenal of drug candidates against a wide range of diseases including cancer and …

Molecular characterization of the anticancer properties associated with bee venom and its components in glioblastoma multiforme

AA Lebel, MV Kisembo, MFN Soucy… - Chemico-Biological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a frequent form of malignant glioma. Strategic therapeutic
approaches to treat this type of brain tumor currently involves a combination of surgery …

Bioactive peptides from venoms against glioma progression

B Majc, M Novak, TT Lah, I Križaj - Frontiers in Oncology, 2022 - frontiersin.org
Venoms are complex mixtures of different molecules and ions. Among them, bioactive
peptides have been found to affect cancer hallmarks, such as cell proliferation, cell invasion …