Ketamine is a phencyclidine derivative that acts as a noncompetitive N-methyl-D-aspartate
as well as a glutamate receptor antagonist. It also has other minor mechanisms that …

Introduction Ketamine is gaining renewed interest among healthcare providers in the
emergency department (ED) setting due to its novel clinical applications. Areas covered This …

Sickle cell disease (SCD) is an inherited disorder that impairs red blood cells (RBCs) and
disrupts the delivery of oxygen to tissues. There is currently no cure. Symptoms can appear …

Purpose Opioids are widely used to treat painful vaso-occlusive crises (VOC) in sickle cell
disease (SCD). However, due to opioids' significant adverse effect profiles, the search for …

Comprehensive assessment, pain and ventilatory management during acute complications of
adult sickle cell disease: A clinical practice survey in French intensive care units …

This chapter provides an overview of the pharmacology of commonly used analgesics and
adjuvant medications. Children and young people (CYP) are unique because of …

Introduction Patients with sickle cell disease (SCD) present recurrent episodes of acute pain,
the hallmark of the disease, and some will also develop chronic pain. Currently, the …

Sickle cell disease is prevalent in large numbers of patients in the United States and has a
significant global impact. Its complications span numerous organs and lead to reduced life …

Ketamine has a long and very eventful pharmacological history. Its enantiomer, esketamine
((S)‐ketamine), was approved by the US Food and Drug Administration (FDA) and EMA for …

Dear Editor, I read the systematic review article regarding ketamine infusion for vaso‑
occlusive crisis (VOC) in patients with sickle cell disease (SCD) published in the January …