Oligodendrocytes are highly specialized glial cells, responsible for producing myelin in the
central nervous system (CNS). The multi-stage process of oligodendrocyte development is …

Myelination has evolved as a mechanism to ensure fast and efficient propagation of nerve
impulses along axons. Within the central nervous system (CNS), myelination is carried out …

Neuroprotective, anti-inflammatory, and remyelinating properties of androgens are well-
characterized in demyelinated male mice and men suffering from multiple sclerosis …

Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction
of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to …

Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-
autonomous loss of individual genes can result in different regional phenotypes. However, a …

Objective Myelin regeneration in the human central nervous system relies on progenitor
cells within the tissue parenchyma, with possible contribution from previously myelinating …

In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and
subsequent neuronal degeneration throughout the CNS impair patient functionality. While …

In the vertebrate CNS, oligodendrocytes produce myelin, a specialized membrane, to
insulate and support axons. Individual oligodendrocytes wrap multiple axons with myelin …

Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the
mammalian target of rapamycin (mTOR) pathway dysregulation. It provides the rational …

Aims We aim to evaluate if the myelin pathology observed in epilepsy‐associated focal
cortical dysplasia type 2B (FCD2B) and—histologically indistinguishable—cortical tubers of …