Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

E Takematsu, A Spencer, J Auster, PC Chen… - PLoS …, 2020 - journals.plos.org
Non-healing chronic ulcers are a serious complication of diabetes and are a major
healthcare problem. While a host of treatments have been explored to heal or prevent these …

Genetic variants associated with Alzheimer disease in the 22 Arab countries: a systematic review

HF Al-Thani, MN Ahmad, S Younes… - Alzheimer Disease & …, 2021 - journals.lww.com
Results: In total, 18 studies were included, comprising a total of 2173 individuals, of whom
888 were clinically diagnosed AD patients and were genetically tested for genes and …

Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait

A Rahman, M Abu-Farha, A Channanath… - Frontiers in …, 2023 - frontiersin.org
Vitamin D deficiency (VDD) is widespread in the Arab world despite ample sunshine
throughout the year. In our previous study, lifestyle and socio-demographic factors could …

GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study

SA Mohamed, J Fernadez-Tajes, PW Franks, L Bennet - BMC medicine, 2022 - Springer
Background Type 2 diabetes is one of the leading causes of chronic kidney failure, which
increases globally and represents a significant threat to public health. People from the …

Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics

SE John, D Antony, M Eaaswarkhanth, P Hebbar… - Scientific reports, 2018 - nature.com
Consanguineous populations of the Arabian Peninsula have been underrepresented in
global efforts that catalogue human exome variability. We sequenced 291 whole exomes of …

Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6TMC8 and SIX3SIX2 loci associated with HbA1c

T Hachiya, S Komaki, Y Hasegawa, H Ohmomo… - Scientific reports, 2017 - nature.com
Glycated haemoglobin (HbA1c) is widely used as a biomarker for the diagnosis of diabetes,
for population-level screening, and for monitoring the glycaemic status during medical …

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population

P Hebbar, JA Abubaker, M Abu-Farha, O Alsmadi… - Human genetics, 2021 - Springer
While the Arabian population has a high prevalence of metabolic disorders, it has not been
included in global studies that identify genetic risk loci for metabolic traits. Determining the …

Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population

P Hebbar, R Nizam, M Melhem, F Alkayal, N Elkum… - Journal of lipid …, 2018 - ASBMB
Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although
many genetic variants associated with blood lipid traits have been identified in Europeans …

Generalizability of GWA-identified genetic risk variants for metabolic traits to populations from the arabian Peninsula

P Hebbar, M Abu-Farha, J Abubaker, AM Channanath… - Genes, 2021 - mdpi.com
The Arabian Peninsula, located at the nexus of Africa, Europe, and Asia, was implicated in
early human migration. The Arab population is characterized by consanguinity and …

[HTML][HTML] Association between greenness and dyslipidemia in patients with coronary heart disease: a proteomic approach

J Guo, J Wu, D Wei, T Wang, Y Hu, Y Lin… - Ecotoxicology and …, 2022 - Elsevier
Background Residential surrounding greenness may be protective of dyslipidemia are often
theorized but remain poorly quantified. In particular, the underlying biological mechanisms …