Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

Background Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic,
chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The …

Psychiatric disorders are highly genetically correlated, but little research has been
conducted on the genetic differences between disorders. We developed a new method …

Understanding axon regenerative failure remains a major goal in neuroscience, and
reversing this failure remains a major goal for clinical neurology. Although an inhibitory …

Previous studies indicate that conditional genetic deletion of phosphatase and tensin
homolog (PTEN) in neonatal mice enhances the ability of axons to regenerate following …

Differentiated oligodendrocytes produce myelin and thereby ensure rapid nerve impulse
conduction and efficient information processing in the vertebrate central nervous system …

Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in
complex tissues, however, spatial orientation is lost. Here, we present single-cell …

Cytokine-induced activation of signal transducer and activator of transcription 3 (STAT3)
promotes the regrowth of damaged axons in the adult central nervous system (CNS). Here …