The numerous processes that damage DNA are counterbalanced by a complex network of
repair pathways that, collectively, can mend diverse types of damage. Insights into these …

Aging is a natural and unavoidable part of life. However, aging is also the primary driver of
the dominant human diseases, such as cardiovascular disease, cancer, and …

DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …

Environmental stress can cause mutation or genomic instability in stem cells which, in some
cases, leads to tumorigenesis. Mechanisms to monitor and eliminate these mutant stem cells …

Werner syndrome (WS) is a rare genetic disease in humans, caused by mutations in the
WRN gene that encodes a protein containing helicase and exonuclease domains. WS is …

Synapses grow, prune, and remodel throughout development, experience, and disease.
This structural plasticity can destabilize information transfer in the nervous system. However …

The cellular mechanisms of meiosis are critical for proper gamete formation in sexual
organisms. Functional studies in model organisms have identified genes essential for …

As organisms age, their resistance to stress decreases while their risk of disease increases.
This can be shown in patients with Werner syndrome (WS), which is a genetic disease …

The absence of functional BLM DNA helicase, a member of the RecQ family of helicases, is
responsible for the rare human disorder Bloom Syndrome, which results in developmental …

Werner syndrome (WS) is an autosomal recessive progeroid disease characterized by
patients' early onset of aging, increased risk of cancer and other age-related pathologies …