Phage transmission strategies: are phages farming their host?

Y Casters, LE Bäcker, K Broux, A Aertsen - Current Opinion in Microbiology, 2024 - Elsevier
Extensive coevolution has led to utterly intricate interactions between phages and their
bacterial hosts. While both the (short-term) intracellular molecular host-subversion …

Phage-induced efflux down-regulation boosts antibiotic efficacy

S Kraus, ML Fletcher, U Łapińska, K Chawla… - PLoS …, 2024 - journals.plos.org
The interactions between a virus and its host vary in space and time and are affected by the
presence of molecules that alter the physiology of either the host or the virus. Determining …

Cas10 relieves host growth arrest to facilitate spacer retention during type III-A CRISPR-Cas immunity

N Aviram, AK Shilton, NG Lyn, BS Reis, A Brivanlou… - Cell Host & Microbe, 2024 - cell.com
Cells from all kingdoms of life can enter growth arrest in unfavorable environmental
conditions. Key to this process are mechanisms enabling recovery from this state …

Nonlinear regulatory dynamics of bacterial restriction-modification systems modulates horizontal gene transfer susceptibility

M Djordjevic, L Zivkovic, HY Ou… - Nucleic Acids …, 2025 - academic.oup.com
Type II restriction-modification (R–M) systems play a pivotal role in bacterial defense against
invading DNA, influencing the spread of pathogenic traits. These systems often involve …

[HTML][HTML] Novel Insights on Extracellular Electron Transfer Networks in the Desulfovibrionaceae Family: Unveiling the Potential Significance of Horizontal Gene …

V Gonzalez, J Abarca-Hurtado, A Arancibia… - Microorganisms, 2024 - mdpi.com
Some sulfate-reducing bacteria (SRB), mainly belonging to the Desulfovibrionaceae family,
have evolved the capability to conserve energy through microbial extracellular electron …

Antibiotic resistant bacteria survive treatment by doubling while shrinking

A Campey, U Łapińska, R Chait, K Tsaneva-Atanasova… - mBio, 2024 - journals.asm.org
Many antibiotics that are used in healthcare, farming, and aquaculture end up in
environments with different spatial structures that might promote heterogeneity in the …

[HTML][HTML] Reduction of nontyphoidal Salmonella enterica in broth and on raw chicken breast by a broad-spectrum bacteriophage cocktail

T Brenner, DM Schultze, D Mahoney, S Wang - Journal of Food Protection, 2024 - Elsevier
Globally, nontyphoidal Salmonella (NTS) causes approximately 150 million foodborne
illnesses annually; many of which are linked to poultry products. Thus, improving food safety …

Investigation into scalable and efficient enterotoxigenic Escherichia coli bacteriophage production

KG Wiebe, BWM Cook, TJ Lightly, DA Court… - Scientific Reports, 2024 - nature.com
As the demand for bacteriophage (phage) therapy increases due to antibiotic resistance in
microbial pathogens, strategies and methods for increased efficiency, large-scale phage …

Determinants in the phage life cycle: The dynamic nature of ssDNA phage FLiP and host interactions under varying environmental conditions and growth phases

K Mäkelä, E Laanto… - Environmental …, 2024 - Wiley Online Library
The influence of environmental factors on the interactions between phages and bacteria,
particularly single‐stranded DNA (ssDNA) phages, has been largely unexplored. In this …

Evolutionary and coevolutionary phage training approaches enhance bacterial suppression and delay the emergence of phage resistance

L Ngiam, K Weynberg, J Guo - ISME Communications, 2024 - academic.oup.com
The development of phage resistance by bacteria is a major barrier that impedes the
therapeutic use of phage. Phage training has been proposed as a novel tool that harnesses …