Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds

J Beltrán, PJ Steiner, M Bedewitz, S Wei… - Nature …, 2022 - nature.com
A general method to generate biosensors for user-defined molecules could provide
detection tools for a wide range of biological applications. Here, we describe an approach …

[HTML][HTML] Development of abscisic acid receptor agonists/antagonists and their application prospect in agriculture: An overview

X Tang, X Li, Z Qin - Advanced Agrochem, 2024 - Elsevier
Abscisic acid (ABA), a plant hormone, is crucial for regulating various physiological and
developmental processes in plants, including adaptation to biotic and abiotic stresses …

Dynamic control of plant water use using designed ABA receptor agonists

AS Vaidya, JDM Helander, FC Peterson, D Elzinga… - Science, 2019 - science.org
INTRODUCTION Climate extremes create a need to mitigate the effects of drought on
agriculture. The contributions of water to crop yield vary over a growing season but peak …

Next-generation ABACUS biosensors reveal cellular ABA dynamics driving root growth at low aerial humidity

J Rowe, M Grangé-Guermente, M Exposito-Rodriguez… - Nature Plants, 2023 - nature.com
The plant hormone abscisic acid (ABA) accumulates under abiotic stress to recast water
relations and development. To overcome a lack of high-resolution sensitive reporters, we …

Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo

AS Vaidya, FC Peterson, J Eckhardt… - Proceedings of the …, 2021 - National Acad Sciences
Abscisic acid (ABA) is a key plant hormone that mediates both plant biotic and abiotic stress
responses and many other developmental processes. ABA receptor antagonists are useful …

Synthesis, plant growth regulatory activity, and transcriptome analysis of novel opabactin analogs

X Tang, M Chen, X Li, X Zhang, P Wang… - Journal of Agricultural …, 2024 - ACS Publications
Abscisic acid (ABA), a phytohormone, and its analogs have been found to enhance plant
resistance to various biotic and abiotic stresses, particularly drought, by activating the ABA …

A theranostic abscisic acid-based molecular glue

J Chen, HTX Nguyen, M Yang, F Zeng, H Xu… - Chemical …, 2023 - pubs.rsc.org
Molecular glues, capable of selectively controlling the interactions between specific pairs or
groups of proteins and the associated downstream effects, have become a promising …

New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought

K Yoshida, Y Kondoh, T Nakano, B Bolortuya… - ACS Chemical …, 2021 - ACS Publications
The phytohormone abscisic acid (ABA) plays an important role in plant stress response,
mainly against desiccation. Hence, ABA receptor agonists may function as agents to …

Chemical approaches for improving plant water use

AS Vaidya, SR Cutler - Abscisic Acid: Methods and Protocols, 2022 - Springer
Agricultural productivity in rain-fed crops has been threatened in recent decades due to
increased instances of drought and diminishing freshwater resources. This has led to the …

Synthesis and Exploration of Abscisic Acid Receptor Agonists Against Dought Stress by Adding Constraint to a Tetrahydroquinoline‐Based Lead Structure

G Bojack, R Baltz, J Dittgen, C Fischer… - European Journal of …, 2021 - Wiley Online Library
New oxotetrahydroquinolinyl‐and oxindolinyl sulfonamides interacting with
RCAR/(PYR/PYL) receptor proteins were identified as lead structures against drought stress …